RESEARCH ASSOCIATE - Epigenetic Regulation of Lymphocyte Activation & Terminal Differentiation

DEPARTMENT: Cincinnati Children's Research Foundation, CCHMC Affiliates

SUPERVISOR'S TITLE: Principal Investigator

TITLES SUPERVISED: NA

TOTAL NUMBER OF FTE's DIRECTLY OR INDIRECTLY SUPERVISED: 0

PURPOSE OF POSITION: To conduct independent and directed scientific studies and research in support of a Principal Investigator's research for a Medical Center.

Dr. Andrew Lindsley's Lab at Cincinnati Children's Hospital has an opening for a Research Associate /Staff Scientist to study the epigenetic regulation of lymphocyte activation and terminal differentiation. Research in the Lindsley Lab focuses on congenital epigenetic diseases which exhibit an immune phenotype. Using established mouse model systems and patient-derived specimens they investigate the molecular mechanisms driving disease pathology and test the efficacy of emerging therapies.

Website: https://www.cincinnatichildrens.org/bio/l/andrew-lindsley

Responsibilities
·Conduct Research
Design, execute and record laboratory experiments; apply standard scientific/research protocols to experiments, research and improve current methods and evaluate innovative techniques. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments. Develop, set-up and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.
·Publish
Draft, write and edit scientific reports, papers, journal articles and abstracts. Present at local, national and international scientific meetings.
·Teamwork
Train and supervise the work of other laboratory personnel as appropriate. Maintain an integral role in the laboratory's meetings, presentations and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
·Financial Management
Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
·Leadership
May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.

EDUCATION\WORK EXPERIENCE:
Required:

•Ph.D., M.D or equivalent degree in related discipline.
•3 years of related postdoctoral experience
Candidates with a strong background in mouse/human immunology and/or epigenetics are encouraged to apply. In particular, experience with human/mouse lymphocytes (in vivo vaccination protocols andin vitro differentiation protocols) and flow cytometry will be highly advantageous. Experience in basic molecular techniques including gene expression quantification (RT-PCR), protein analysis (ELISA, Western) and immunohistochemistry are required.

REQUIRED SKILLS: Excellent written, verbal and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, presentation, spreadsheet and database software). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analyses. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments. Ability to express results in the form of oral and written presentations suitable for submission to the peer-reviewed literature. Careful bookkeeping skills. Expertise in technical execution and precision measurements. Presentation of experimental results in a form suitable for extramural funding applications.