Cincinnati Children's Hospital Medical Center - Research Careers

Research Jobs
at Cincinnati Children's Hospital Medical Center

Full Job Title: RESEARCH ASSOCIATE - Xenbase Biocurator

Job Number: 94182

Location: Cincinnati, OH

Date Posted: 8-17-2017

Xenbase ( is the NIH-funded, Xenopus model organism. Xenopus is a major model for fundamental cell and developmental biology and human disease modeling. Xenbase curates and integrates all of the Xenopus literature, gene expression, phenotype, bioinformatics and genomics data and makes it available to the international research community supporting data exchanges with NCBI, USCS and other model organism databases.

We are seeking a highly motivated, collaborative individual to join the Xenbase Biocuration team located in the Division of Developmental Biology. This position positions offer a challenging job away from the wet-lab and research bench, where interpreting, annotating and displaying complex data is our main task. Curators also develop strategies to improve data curation; work to improve data display/querying on the website; interact with our user community at research conferences; develop programming skills; and contribute to Xenbase publications.

Job Description:
• Curation and annotation of published Xenopus scientific literature, focusing on gene expression and the extraction of other research data: genes, transgenic constructs, antibodies, phenotypes, genetic interactions, gene product functions and models of human disease.
• Import and annotate data from large-scale screens.
• Help develop new features: curation and processing of public and directly submitted RNA-seq and ChIP-seq NGS data from Xenopus experiments, curation of mutant phenotypes and transgenics; implementing GO annotations.
• Co-author reports and publications, and give presentations at national and international meetings and workshops.
•Teamwork: Train and supervise the work of other laboratory personnel as appropriate. Maintain an integral role in the laboratory's meetings, presentations and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
•Financial Management: Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
•Leadership: May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.

• PhD degree in bioinformatics and/or developmental biology, genomics, genetics, molecular biology, zoology, anatomy or related field.
• Demonstrated ability to produce scientific papers, reports and presentations
• Demonstrated ability to work in a team as well as independently, efficiently (i.e., both quickly and accurately) and be self-motivated
• Strong interpersonal and communication skills, including excellent written and spoken English.

Preference will be given to an applicant with:
• Experience with a bioinformatics, genomics or model organism database
• Experience in data annotation/biocuration, knowledge of relational databases, and familiarity with ontologies.
• Experience in a Xenopus or other vertebrate (mouse, zebrafish or chick) developmental biology.
• Experience in analyzing genomics data, using GRN software, genome browsers and common bioinformatics tools.

REQUIRED SKILLS: Excellent written, verbal and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, presentation, spreadsheet and database software). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analyses. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments. Ability to express results in the form of oral and written presentations suitable for submission to the peer-reviewed literature. Careful bookkeeping skills. Expertise in technical execution and precision measurements. Presentation of experimental results in a form suitable for extramural funding applications.

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