Cincinnati Children's Hospital Medical Center - Research Careers

Research Jobs
at Cincinnati Children's Hospital Medical Center

Full Job Title: RESEARCH ASSOCIATE - Autoimmune Genomics

Job Number: 87043

Location: Cincinnati, OH

Date Posted: 9-14-2017

POSITION TITLE: RESEARCH ASSOCIATE

DEPARTMENT: Cincinnati Children's Research Foundation, CCHMC Affiliates

SUPERVISOR'S TITLE: Principal Investigator

TITLES SUPERVISED: NA

TOTAL NUMBER OF FTE's DIRECTLY OR INDIRECTLY SUPERVISED: 0

PURPOSE OF POSITION: To conduct independent and directed scientific studies and research in support of a Principal Investigator's research for a Medical Center.

Genomic technologies (ChIP-seq, EMSA, DAPA, ATAC-seq, DNA methylation, and others) are being applied in Dr. Harley's laboratory to reconcile genetic associations with the environmental causes of idiopathic autoimmune disorders with the goal to elucidate mechanisms initiating these pathological processes. The candidate would join a team that has uncovered unexpected and powerful associations of transcription factors with genetic loci, with the goal to establish the genetic origin of the preliminary findings experimentally. The team in place has the strategic, informatic, clinical, and technical expertise to provide strong support for the candidate in addition to the other resources and personnel of the Center for Autoimmune Genomics and Etiology (CAGE) (https://www.cincinnatichildrens.org/research/divisions/a/genomics-etiology/team). The disorders with direct relevance to this position include lupus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, inflammatory bowel disease, chronic lymphocytic leukemia, and many others.

MAJOR DUTIES AND RESPONSIBILITIES:
•Conduct Research: Design, execute and record laboratory experiments; apply standard scientific/research protocols to experiments, research and improve current methods and evaluate innovative techniques. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments. Develop, set-up and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.

•Publish: Draft, write and edit scientific reports, papers, journal articles and abstracts. Present at local, national and international scientific meetings.

•Teamwork: Train and supervise the work of other laboratory personnel as appropriate. Maintain an integral role in the laboratory's meetings, presentations and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication

•Financial Management: Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.

•Leadership: May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.

EDUCATION\WORK EXPERIENCE:
Required:

•Ph.D., M.D or equivalent degree in related discipline.
•3 years of related postdoctoral experience
. The ideal candidate will have a PhD with training in genomic molecular laboratory methods (e.g., ChIP-seq, CRISPR-Cas9, EMSA, DAPA, etc.) as well as deep familiarity with genome wide association studies for any complex genetic disease phenotype. Preference will be given to applicants with experience with the analysis of next generation sequence data, large genotyping datasets, and data mining in general along with demonstrated scholarly productivity by discovery and publication.

REQUIRED SKILLS: Excellent written, verbal and interpersonal communication skills. Demonstrate attention to detail, strong organizational skills, supervisory ability and an innovative approach to experimental design. Computer literate and working knowledge of software applications (word processing, presentation, spreadsheet and database software). Analytical ability sufficient to compare data; mathematical ability sufficient to perform algebraic calculations and statistical analyses. Ability to synthesize information and to create and deal with new situations by applying past experiences. Expressed willingness to teach others and share results. Capable of meeting time demands necessary to execute experiments. Ability to express results in the form of oral and written presentations suitable for submission to the peer-reviewed literature. Careful bookkeeping skills. Expertise in technical execution and precision measurements. Presentation of experimental results in a form suitable for extramural funding applications.

Cincinnati Children’s is an Equal Opportunity Employer. Qualified applicants receive consideration for employment without regard to race, color, religion, sex, national origin, age, genetic information, physical or mental disability, military or veteran status, sexual orientation, gender identity/expression, or other protected status in accordance with applicable federal, state, and local laws and regulations. If you would like more information about equal employment opportunity (EEO) rights as an applicant under the law, please click here

Cincinnati Children’s will not discriminate against applicants and employee for inquiring about, discussing or disclosing their pay or, in certain circumstances, the pay of their co-workers. If you would like more information about the Pay Transparency Nondiscrimination Provision, please click here