POSITION TITLE: RESEARCH ASSOCIATEDEPARTMENT:
Cincinnati Children's Research Foundation, CCHMC AffiliatesSUPERVISOR'S TITLE:
Principal InvestigatorTITLES SUPERVISED:
NATOTAL NUMBER OF FTE's DIRECTLY OR INDIRECTLY SUPERVISED:
0PURPOSE OF POSITION:
To conduct independent and directed scientific studies and research in support of a Principal Investigator's research for a Medical Center.
Genomic technologies (ChIP-seq, EMSA, DAPA, ATAC-seq, DNA methylation, and others) are being applied in Dr. Harley's laboratory to reconcile genetic associations with the environmental causes of idiopathic autoimmune disorders with the goal to elucidate mechanisms initiating these pathological processes. The candidate would join a team that has uncovered unexpected and powerful associations of transcription factors with genetic loci, with the goal to establish the genetic origin of the preliminary findings experimentally. The team in place has the strategic, informatic, clinical, and technical expertise to provide strong support for the candidate in addition to the other resources and personnel of the Center for Autoimmune Genomics and Etiology (CAGE) (https://www.cincinnatichildrens.org/research/divisions/a/genomics-etiology/team
). The disorders with direct relevance to this position include lupus, rheumatoid arthritis, multiple sclerosis, type 1 diabetes, inflammatory bowel disease, chronic lymphocytic leukemia, and many others.MAJOR DUTIES AND RESPONSIBILITIES:
•Conduct Research: Design, execute and record laboratory experiments; apply standard scientific/research protocols to experiments, research and improve current methods and evaluate innovative techniques. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments. Develop, set-up and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats. Discuss relevant insights about experimental results with Director and provide useful recommendations and analysis. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks. Demonstrate performance at work, consistency in carrying out instructions, accuracy & attention to detail, achieving expected results & continuous improvement.
•Publish: Draft, write and edit scientific reports, papers, journal articles and abstracts. Present at local, national and international scientific meetings.
•Teamwork: Train and supervise the work of other laboratory personnel as appropriate. Maintain an integral role in the laboratory's meetings, presentations and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs and seminars. Demonstrate attendance and punctuality, ability to work independently & display initiative and dedication
•Financial Management: Assist in preparing, writing and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests. Prepare, approve and initiate check requests; track funding, maintain accurate balance and resolve any discrepancies.
•Leadership: May act as a mentor to more junior staff, serve as the contact for resolution of complex issues, provide education, guidance and work direction. May provide input and feedback to managers on hiring decisions, professional development and performance management.